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乐学义

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一、个人基本资料

姓名:乐学义

性别:男

出生年月:1961.07

籍贯:湖北武穴

二、联系方式

邮箱:lexy@scau.edu.cn

通讯地址:广州市华南农业大学材料与能源学院

邮编:510642

三、个人简述

博士, 教授,博/硕士研究生导师。中国化学会终身会员,兼任广东省化工学会副理事长、广东省化学会常务理事、广东省高等学校化工委员会理事、《华南农业大学学报》及《广东化工》编委等。长期从事生物无机化学、药物化学、食品科学等交叉学科研究,先后承担省部级以上科研项目20余项,已公开发表学术论文180多篇,其中90余篇被SCI收录,获得国家发明专利2,作为主要参加人获广东省自然科学一等奖1,合作出版编著1本。

四、教育背景

1978/09-1982/07, 湖北师范大学化学系本科生

1985/09-1988/06, 华中师范大学化学系硕士研究生

1993/09-1996/06, 中山大学化学化工学院博士研究生

五、工作经历

1982/08-1985/08, 湖北省应城市教师进修学校化学教师

1988/06-1993/08, 湖北工程学院化学系讲师

1996/07-1997/12, 华南农业大学理学院讲师

1997/12-2001/12, 华南农业大学理学院副教授硕士研究生导师(1999/06-),期间担任应用化学系副主任(2001/03-2001/04) 理学院副院长兼任应用化学系主任(2001/05- 2006/12

2001/12-2014/12华南农业大学理学院教授(破格)博士研究生导师(2005/06-),期间担任理学院院长(2007/01-2014/12

2015/01-现在,华南农业大学材料与能源学院应用化学系教授

六、科研方向

具有抗菌、抗肿瘤等活性的化学新药研制与开发;具有抗氧化、抗菌等功能性作用的食品保鲜剂及添加剂的研究与应用;仿生材料及生物质材料的研究与应用。

七、代表性科研论文

1Yong-Yu Qi, Qian Gan , Ya-Xian Liu, Ya-Hong Xiong, Zong-Wan Mao, Xue-Yi Le*. Two new Cu(II) dipeptide complexes based on 5-methyl-2-(2’-pyridyl)benzimidazole as potential antimicrobial and anticancer drugs:Special exploration of their possible anticancer mechanism.European Journal of Medicinal Chemistry, 2018, 154, 220-232.

2Chun-Lian Zhang, Ya-Xian Liu, Xue-Mei Zhang, Shi Chen, Fang Shen, Ya-Hong Xiong, Wei Liu,, Zong-Wan Mao, Xue-Yi Le*. Synthesis, characterization, DNA/HSA interactions and in vitro cytotoxic activities of two novel water-soluble copper(II) complexes with 1,3,5-triazine derivative ligand and amino acids. Materials Science & Engineering C, 2018, 91,414-425.

3Yujia Liu, Danyang Ying, Luz Sanguansri, Yanxue Caib, Xueyi Le*. Adsorption of catechin onto cellulose and its mechanism study: Kinetic models, characterization and molecular simulation. Food Research International, 2018, 12, 225-232.

4Yujia Liu, Yanxue Cai, Danyang Ying, Yinlian Fu, Yahong Xiong, Xueyi Le*. Ovalbumin as a carrier to significantly enhance the aqueous solubility and photostability of curcumin: Interaction and binding mechanism study. International Journal of Biological Macromolecules, 2018, 116, 893900.

5Chunlian Zhang, Xuemei Zhang,Wei Liu, Shi Chen*, Zong-Wan Mao, Xue-Yi Le*. Synthesis, crystal structures and DNA/human serum albumin binding of ternary Cu(II) complexes containing amino acids and 6(pyrazin2yl)1,3,5triazine2,4diamino. Appllied Organometallic Chemistry, 2018,32(2) , DOI: 10.1002/aoc.3994.

6Yongyu Qi, Yaxian Liu, Qian Gan, Yahong Xiong, Zongwan Mao, Xueyi Le*. Three new mixedligand copper(II) complexes containing glycylLvaline and N,Naromatic heterocyclic compounds: Synthesis, characterization, DNA interaction, cytotoxicity and antimicrobial activity. Appllied Organometallic Chemistry, 2018,32(3) , DOI: 10.1002/aoc.4126.

7Fang Shen,Yaxian Liu,Shumin Li,Chikun Jiang,Bingfeng Wang, Yahong Xiong*, Zongwan Mao,Xueyi Le*, Synthesis, crystal structures, molecular docking and in vitro cytotoxicity studies of two new copper(II) complexes: special emphasis on their binding to HAS, New Journal of Chemistry, 2017, 41, 12429-12441.

8Yujia Liu, Danyang Ying, Yanxue Cai, Xueyi Le*, Improved antioxidant activity and physicochemical properties of curcumin by adding ovalbumin and its structural characterization. Food Hydrocolloids, 2017,72, 304-311.

9Qian Gan, Chun-Lian Zhang, Bing-Feng Wang, Ya-Hong Xiong, Zong-Wan Mao, Xueyi Le*. Two new mixed copper(II)–dipeptide complexes of N,N-donor heterocycle ligands: studies on their non-covalent DNA binding, chemical nuclease, antioxidant and anticancer activities. RSC Advances, 2016, 6, 35952-35965.

10Yujia Liu, Yanxue Cai, Xueying Jiang, Jinping Wu, Xueyi Le*. Molecular interactions, characterization and antimicrobial activity of curcumin-chitosan blend films. Food Hydrocolloids, 2016, 52, 564-572.

11Xia-Bing Fu, Jia-Jia Zhang, Dan-Dan Liu, Qian Gan, Hong-Wei Gao, Zong-Wan Mao, Xue-Yi Le*. Cu(II)–dipeptide complexes of 2-(4′-thiazolyl)benzimidazole: Synthesis, DNA oxidative damage, antioxidant and in vitro antitumor activity. Journal of Inorganic Biochemistry, 2015, 143, 77-87.

12Yujia Liu, Dandan Liu, Li Zhu, Qian Gan, Xueyi Le*,Temperature-dependent structure stability and in vitro release of chitosan-coated curcumin liposome. Food Research International, 2015, 74, 97-105.

13Xia-Bing Fu, Dan-Dan Liu, Yuan Lin, Wei Hu, Zong-Wan Mao and Xue-Yi Le*. Water-soluble DNA minor groove binders as potential chemotherapeutic agents: synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions. Dalton Transaction, 2014, 43, 8721-8737.

14Xia-Bing Fu, Gui-Tian Weng, Dan-Dan Liu, Xue-Yi Le*, Synthesis, characterization, DNA binding and cleavage, HAS interaction and cytotoxicity of a new copper(II) complex derived from 2-(2’- pyridyl)benzothiazole and glycylglycine. Journal of Photochemistry and Photobiology A: Chemistry, 2014,276, 83-95.

15Wei Hu, Suwen Deng, Jianyin Huang, Yanmei Lu, Xueyi Le*, Wenxu Zheng*. Intercalative interaction of asymmetric copper(II) complex with DNA: Experimental, molecular docking, molecular dynamics and TDDFT studies.Journal of Inorganic Biochemistry, 2013,127, 90-98.

八、主持科研项目

1高抗氧化活性黄酮类金属配合物研制及应用.广东省科技计划项目,2017/01 - 2019/12

2新型靶向Topo铜配合物的设计合成及其抗肿瘤活性. 广东省自然科学基金面上项目,2015/08-2018/08

3双胍基化壳聚糖研制及其涂膜保鲜水果研究.广东省科技计划项目,2012/01-2014/12

4新型靶向抗菌配合物的设计、合成及生物活性研究.广东省自然科学基金面上项目,2010/10-2012/10

5新型α-氨基酸-金属离子-苯并咪唑衍生物复合抗菌剂的研制及其应用. 广东省科技计划项目,2009/07-2012/06

九、获奖情况

1混配配合物的生物功能作用机制及其应用探索1996获广东省自然科学一等奖(排名第九)

2华南农业大学国邦助教奖(1999)

3华南农业大学科学研究先进工作者(2001)

4广东省千百十工程校级学术骨干培养对象先进个人(2002)

5华南农业大学三育人先进个人(2014)

6.   华南农业大学优秀共产党员(2003, 2015)