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  • 生物无机及分析团队

    发布者:材料与能源学院  发布时间:2020-05-18  浏览次数:837

     、基本情况介绍
       1
    、团队简介

    本团队为“生物无机及分析团队”,主要研究方向为金属配合物、有机-无机杂化荧光探针、生物传感器。主要开展具有抗肿瘤、抗菌等活性的金属配合物的设计,并通过细胞技术与荧光成像技术研究其活性与响应机制;利用荧光技术与纳米材料技术合成有机-无机杂化生物荧光探针,探索新型核酸扩增技术与链杂交技术,制备高灵敏的生物传感器,并探索其在农业病虫害防疫中的应用;制备具有生物活性的功能化纳米材料与柔性电极,利用生物技术与纳米材料技术增强响应信号,并设计相关程序与设备实现便携检测,实现在食品安全方面的应用。

    团队联系人及邮件:weipeng_liu@scau.edu.cn

    2、团队负责人简介

     刘英菊女,19787月出生,博士,教授,博士生导师。1996-2000年,湖南大学化学专业本科毕业;2000-2005年,湖南大学分析化学专业(化学/生物传感与化学计量学国家重点实验室)硕博连读,获理学博士学位;2005.7至今,在华南农业大学从事化学教学与科研工作。2011.3-2012.3,日本东北大学环境研究科和原子分子材料科学高等研究机构(WPI-AIMR)访问学者;2012.12,广东省千百十工程省级培养对象;2017.3,广东省特支计划科技创新青年拔尖人才。长期从事生物传感器和仪器研制研究,主持国家自然科学基金等各类科研项目10余项,在国际、国内期刊发表学术论文60多篇,引用2000多次,获授权中国专利5项。

    联系邮件:yingjuliu@scau.edu.cn
      3
    、团队骨干介绍
     乐学义,男,19617月生,博士,教授,博士生导师,中国化学会高级会员。19939-19966月中山大学化学与化工学院攻读博士学位;19967月来华南农业大学工作。长期从事生物无机化学和食品化学研究,主持和主要参加省部级以上科研课题20多项,公开发表学术论文180多篇,其中90多篇被SCI收录,SCI他引1200多次。申请发明专利5项,授权2项。担任国内外20余种SCI学术刊物论文审稿人及省部级以上科研项目和科技奖的评审专家。

    联系邮件:lexy@scau.edu.cn
    赵月春,女,196411月生,博士,教授,硕士生导师。1997年获华南理工大学博士学位。20007月在华南农业大学理学院从事教学科研工作;20151月至今在华南农业大学材料与能源学院从事教学科研工作。主要从事天然产物的分离纯化、功能性成分制剂化技术及环境有机污染的生物修复的研究,主持完成了广东省科技计划项目、教育部回国留学人员科研启动基金和广州市科技计划项目等多项课题研究工作。在国内外核心期刊发表论文30多篇。获得国家发明专利4项。

    联系邮件:yczhao@scau.edu.cn

    陈实,女,19689月生,博士,副教授。1986年桂林理工大学化探系岩矿分析专业本科毕业;1993年湖南大学化学与化工学院分析化学专业硕士研究生毕业,2010年获华南农业大学生态学博士学位。1993年至今,在华南农业大学从事化学教学与科研工作。多年来从事小分子药物的设计、合成及应用、天然产物的综合利用与开发、分析化学等领域的研究。迄今为止,以第一作者或通讯作者发表SCI论文10余篇。作为主要参与者获授权中国发明专利1项。参与了多项包括国家重大课题子项目、国家自然科学基金在内的各类科研项目。

    刘伟鹏,男,19879月生,博士,首聘副教授,硕士生导师。2010年本科毕业于山东大学;2016年获华南师范大学博士学位。2016.07至今,华南农业大学材料与能源学院工作。本人长期从事核酸分子诊断、电化学发光、纳米材料制备等领域的应用研究。迄今为止,以第一作者或通讯作者在Analytical ChemistryBiosensors & BioelectronicsJournal of Materials Chemistry A等杂志上发表SCI论文10余篇。主持国家自然科学基金青年项目和广东省自然科学基金面上项目。

    联系邮件:weipeng_liu@scau.edu.cn

    何良,男,19877月生,博士,首聘副教授,硕士生导师。2011年本科毕业于中山大学;2016年获中山大学博士学位。2016.09-2018.08在中山大学化学学院从事专职科研工作。201809月起在华南农业大学材料与能源学院工作。多年来从事靶向型金属抗肿瘤药物、光动力治疗药物以及生物诊疗探针等领域的应用研究。迄今为止,以第一作者或通讯作者在Angew. Chem. Int. Ed.Chem. Sci.Chem. Commun.Sensor. Actuat. B-ChemDalton Trans.等杂志上发表SCI论文10余篇,其中一区论文5篇,二区论文5篇。参与发表SCI论文10余篇。获授权中国发明专利1项。作为负责人主持了包括国家自然科学基金在内的各类科研项目4项。担任Dalton Trans.J. Mater. Chem.SCI期刊的论文审稿人。

    联系邮件:heliang@scau.edu.cn

    秦为为,女,19893月生,博士,首聘副教授,硕士生导师。20167月于中国科学院大学获得理学博士学位,无机化学专业;20167~20188月在中山大学/药学院任特聘副研究员,20189月起在华南农业大学材料与能源学院工作。主要研究方向为利用无机纳米颗粒及DNA纳米结构设计构建生物及农学传感策略。近年来,以第一作者或通讯作者在Angew. Chem., Int. Ed., ACS Appl. Mater. Inter. , Nanoscale等杂志发表SCI论文8篇,合作发表SCI论文10多篇。作为负责人主持国家自然科学基金青年基金项目一项,中央高校基本科研业务费项目一项。

    联系邮件:qinweiwei@scau.edu.cn

    熊亚红,女,19767月生,博士,副教授,2012年入选广东省第四批“千百十工程”校级培养对象。1998.9-2001.7在青岛化工学院(现青岛科技大学)获硕士学位; 2001.9-2004.6在中山大学获理学博士学位;2016.4-2017.4于美国德州大学西南医学中心作访问学者。20047月进入华南农业大学工作以来,致力于功能小分子的设计与合成及分子间的相互作用研究,在抗菌、抗氧化及抗肿瘤活性配合物的合成及其活性机理方面积累了较丰富的经验。作为主要项目参与人参与国家自然科学金项目2项,省级项目6项,主持多项校级项目和1项企业横向项目,发表论文SCI论文10余篇。

    联系邮件:xiongyahong@scau.edu.cn

    王炳锋,男,197811月生,博士,讲师。20047月进入华南农业大学工作。长期从事量子化学计算和分子模拟工作,搭建了理论计算的集群超算中心,完成了药物设计平台和农药靶点数据库等工作。在分子对接和分子动力学方面长期和校内其他团队有紧密合作。主持和完成国家项目2项,发表SCI研究论文10多篇。

    联系邮件:wbfeng@scau.edu.cn

    彭一鸣,女,硕士、讲师。1996.09-2000.7于湖南师范大学化学系,获大学学士学位;2000.09-2003.07 于暨南大学化学系,获理学硕士学位;2003.08-2004.07  广州市职业病防治院中毒检测中心,理化检验员;2004.8-至今, 华南农业大学化学系教师。
     E-mail
    lilypengyiming@163.com

    二、主要研究领域(科研方向)

    1. 生物无机配合物的设计、活性及在农业中的应用机制研究;

    2. 基于功能化纳米材料的生物传感器在食品检测、病虫害检测等的应用研究;

    三、主持项目介绍
    1
    、累计到位经费 
           
    近年来,先后承担各级科研项20多项,包括国家自然科学基金6项、省部级项目10余项,项目总经费700余万元。

     2、科研项目     

    (1) 刘英菊,基于功能化二硫化钼构筑比率型免疫传感器对赭曲霉毒素广谱性识别的研究,国家自然科学基金,2019.1-2022.12.

    (2) 秦为为,新型等离子增强单分子检测体系的构建及其在循环肿瘤DNA的超高灵敏检测与分析中的应用,国家自然科学基金,2018.1-2020.12

    (3) 何良,靶向型磷光金属配合物诱导癌细胞免疫原性死亡的研究,国家自然科学基金,2018.1-2020.12

    (4) 刘伟鹏,基于基因靶向切割的核酸扩增技术构建及其在马铃薯晚疫病检测中的应用,国家自然科学基金,2018.1-2020.12

    (5) 刘英菊,基于仿生磁性石墨烯构筑球形DNA扩增的免疫传感器检测微囊藻毒素的研究,国家自然科学基金,2015.1-2018.12

    (6) 刘英菊,基于生物质碳基纳米材料构筑“双树枝状放大效应”的POPs免疫传感研究,国家自然科学基金,2012.1-2014.1

    (7) 王炳锋,华南及西南水稻农药化肥减视技术集成研究与示范(国家重点研发计划子课题:药肥精准施用跨境跨区域大数据平台),2018-2020

    (8) 何良,磷光金属配合物的光致产酸剂用于乏氧肿瘤的双光子光动力治疗,广东省自然科学基金,2019.10-2022.9

    (9) 何良,靶向型的磷光金属配合物作为抗癌诊疗药物的研究,广东省自然科学基金,2017.5-2020.4

    (10) 刘伟鹏,纳米粒子介导的CRISPR/Cas9系统胞内缓释释放,广东省自然科学基金,2017.5-2020.5

    (11) 乐学义,新型靶向TopoⅠ铜配合物的设计合成及其抗肿瘤活性广东省自然科学基金,2015.08-2018.08

    (12) 刘英菊,广东省特支计划科技创新青年拔尖人才项目,2017.3-2020.3

    (13) 刘英菊,基于多功能的快速检测仪器平台的研制,广东省科技计划项目,2016.5-2018.5

    (14)乐学义, 高抗氧化活性黄酮类金属配合物研制及应用,广东省科技计划项目,2017.01-2019.12

    (15)赵月春,农林废弃物固定化微生物修复农田土壤喹诺酮类抗生素污染的技术研究,2017.01-2018.12

    (16)刘英菊,水中环境激素超痕量检测的便携式免疫传感器的研制,广东省科技计划项目, 2014.8-2016.8

    (17)乐学义,双胍基化壳聚糖研制及其涂膜保鲜水果研究, 广东省科技计划项目, 2012.01-2014.12

    (18)刘英菊,新型仿生磁性纳米材料构筑的生物传感器及其对微囊藻毒素检测的应用,广东省高层次人才项目,2014-2016

    (19)刘英菊,水源水中持久性环境有机污染(POPs)快速检测研究,深圳市水质检测中心,2014.6-2016.6

    (20)何良,肿瘤微环境刺激响应的磷光金属配合物作为抗癌药物的研究,高校基本科研业务费,2017.1-2019.12

    (21)赵月春,食品类胡萝卜素新剂型的研制,横向课题,2018.08-2021.08

    (22) 刘英菊,主要参与,动植物体与环境物质交换传感器开发。广东省重点领域研发计划2019-2021

     四、主要研究成果
       
    1、论文

    (1)    Jie Wei, Huaming Chen, Haihang Chen, Yunyan Cui, Aori Qileng, Weiwei Qin*, Weipeng Liu, Yingju Liu*.. Multifunctional peroxidase-encapsulated nanoliposomes: bioetching- induced photoelectrometric and colorimetric immunoassay for broad-spectrum detection of ochratoxins. ACS Applied Materials Interfaces, 2019, 11, 2383223839

    (2)    Zuyu He, Yue Cai, Ziming Yang, Puwang Li, Hongtao Lei, Weipeng Liu, Yingju Liu*. A dual-signal readout enzyme-free immunosensor based on hybridization chain reaction-assisted formation of copper nanoparticles for the detection of microcystin-LR. Biosensors and Bioelectronics, 2019, 126: 151-159.

    (3)    Yue Cai, Jingkun Fang, Bingfeng Wang, Fangshuai Zhang, Guang Shao, Yingju Liu*. A signal-on detection of organophosphorus pesticides by uorescent probe based on aggregation-induced emission. Sensors and Actuators B: Chemical, 2019, 292: 156-163.

    (4)    Weipeng Liu, Cuifen Gan, Weidan Chang, Aori Qileng, Hongtao Lei,Yingju Liu*. Double-integrated mimic enzymes for the visual screening of Microcystin-LR: Copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme. Analytica Chimica Acta, 2019, 1054: 128-136.

    (5)    Jie Wei, Weidan Chang, AoriQileng, Weipeng Liu, Yue Zhang, ShiyaRong, Hongtao Lei, Yingju Liu*. Dual-modal split-type immunosensor for sensitive detection ofmicrocystin-LR: enzyme-induced photoelectrochemistry andcolorimetry. Analytical Chemistry, 2018, 90: 9606-9613

    (6)    AoriQileng, Jie Wei, Ning Lu, Weipeng Liu, YueCai, Minshi Chen, Hongtao Lei, Yingju Liu*.Broad-specificity photoelectrochemical immunoassay for the simultaneous detection of ochratoxin A, ochratoxin B and ochratoxin C. Biosensors & Bioelectronics, 2018, 106: 219-226.

    (7)    Jie Wei, Xuan Xie, Weidan Chang, Zhuohong Yang, Yingju Liu*. Ultrasensitive photoelectrochemical detection of microcystin-LR based onhybridization chain reaction assisted exciton-plasmon interaction andenzymatic biocatalytic precipitation. Sensors and Actuators B, 2018, 276: 180-188.

    (8)    Aori Qileng, Siyuan Yang, Jie Wei, Ning Lu, Hongtao Lei, Yingju Liu*. Weipeng Liu*. Construction of CdS/Ag2S-based broad-spectrumphotoelectrochemical immunosensor for simultaneous assessment ofochratoxins by multivariable linear regression. Sensors and Actuators B, 2018, 267: 216-223

    (9)    Ruijie Lin, Tongxi Lin, Junying Huang, Xiaohui Huang, Yingju Liu*. Hierarchical cobalt sulfide with vertical in-plane edge structure forenhanced electrocatalytic oxygen evolution reaction. ElectrochimicaActa, 2018, 281: 348-356.

    (10)Aori Qileng, Yue Cai, Jie Wei, Hongtao Lei, Weipeng Liu, Shengsen Zhang*, Yingju Liu*. Construction of CdS/B-TiO2 nanorods photoelectrochemical immunosensor for the detection of microcystin-LR usingSiO2@G-quadruplex as multi-amplifier. Sensors and Actuators B, 2018, 254: 727-735.

    (11)Haoliang Huang, Junying Huang, Weipeng Liu, Yueping Fang*, Yingju Liu*. Ultradispersed and single-layered MoS2 nanoflakes strongly coupling with graphene: an optimized structure with high kinetics for the hydrogen evolution reaction. ACS Applied Materials & Interfaces, 2017, 9: 39380-39390

    (12)Yaqiong Zhang, Lanteng Wang, Xing Shen, Xiaoqun Wei, Xinan Huang*, Yingju Liu*, Xiulan Sun, Zhanhui Wang, Yuanming Sun, ZhenlinXu, Sergei A. Eremin, and Hongtao Lei*. Broad-specificity immunoassay for simultaneous detection of Ochratoxins A, B, and C in Millet and Maize. Journal of Agricultural and Food Chemistry, 2017, 65: 48304838

    (13)Jiahong Chen, Lanteng Wang, Lanlan Lu, Xing Shen, Xin-an Huang*, Yingju Liu, Xiulan Sun, Zhanhui Wang, Sergei AlexandrovichEremin, Yuanming Sun, ZhenlinXu, and Hongtao Lei*. Four specific haptenconformations dominating antibody specificity: quantitative structure-activity relationship analysis for quinolone Immunoassay. Analytical Chemistry, 2017, 89: 6740-6748.

    (14)CuifenGan, Bingfeng Wang, Junying Huang, AoriQileng, Zuyu He, Hongtao Lei, Weipeng Liu*, Yingju Liu*. Multiple amplified enzyme-free electrochemical immunosensor based on G-Quadruplex/Hemin functionalized mesoporous silica with redox-active intercalators for microcystin-LR detection. Biosensors and Bioelectronics, 2017, 98, 126-133.

    (15)Haoliang Huang, Weihao Huang, Zhuohong Yang, Junying Huang, Jiadong Lin, Weipeng Liu*, Yingju Liu*. Strongly coupled MoS2nanoflake-carbon nanotube nanocomposite as an excellent electrocatalyst for hydrogen evolution reaction. Journal of Materials Chemistry A, 2017, 5, 1558-1566 (Hot paper).

    (16)Jie Wei, AoriQileng, Yun Yan, Hongtao Lei, Shengsen Zhang, Weipeng Liu, Yingju Liu*. A novel visible-light driven photoelectrochemical immunosensor based on multi-amplification strategy for ultrasensitive detection of microcystin-LR. AnalyticalChimicaActa, 2017, 994: 82-91.

    (17) Haoliang Huang, Liqin Chen, Chuanhe Liu, Xinshun Liu, Senxuan Fang, Weipeng Liu, Yingju Liu*. Hierarchically nanostructured MoS2 with rich in-plane edges as a high-performance electrocatalyst for the hydrogen evolution reaction. Journal of Materials Chemistry A, 2016, 4, 1457714585

    (18)Cuifen Gan, Li Ling, Zuyu He, Hongtao Lei, Yingju Liu*. In-situ assembly of biocompatible core-shell hierarchical nanostructures sensitized immunosensor for microcystin-LR detection. Biosensors and Bioelectronics, 2016, 78: 381-389.

    (19)Zihong Sun, Weihua Wang, Haibin Wen, Cuifen Gan, Hongtao Lei, Yingju Liu*. Sensitive electrochemical immunoassay for chlorpyrifos by using flake-like Fe3O4 modified carbon nanotubes as the enhanced multienzyme label, Analytica Chimica Acta, 2015, 899: 91-99.

    (20)Zuyu He, Shuai Zang, Yingju Liu*, Yuan He, Hongtao Lei. A multi-walled carbon nanotubes-poly(L-lysine) modified enantioselective immunosensor for ofloxacin by using multi-enzyme-labeled gold nanoflower as signal enhancer. Biosensors Bioelectronics, 2015, 73: 85-92.

    (21)Haoliang Huang, Zuyu He, Xiaomin Lin, Weishuo Ruan, Yingju Liu*, Zhuohong Yang. Ultradispersed platinum nanoclusters on polydopamine-functionalized carbon nanotubes as an excellent catalyst for methanol oxidation reaction. Applied Catalysis A: General, 2015, 490: 65-70

    (22)Yingqiang Huang, Haoliang Huang, Qiongzhi Gao, Cuifen Gan, Yingju Liu*, Yueping Fang. Electroless synthesis of two-dimensional sandwich-like Pt/Mn3O4/reduced- graphene-oxide nanocomposites with enhanced electrochemical performance for methanol oxidation. Electrochimica Acta, 2014, 149: 34-41.

    (23)Zihong Sun, Zhigang Luo, Cuifen Gan, Shidong Fei, Yingju Liu*, Hongtao Lei. Electrochemical immunosensor based on hydrophilic polydopamine-coated prussian blue-mesoporous carbon for the rapid screening of 3-bromobiphenyl. Biosensors & Bioelectronics, 2014, 59: 99-105.

    (24)Haoliang Huang, Yingju Liu*, Qiongzhi Gao, Weishuo Ruan, Xiaomin Lin, Xin Li. Rational construction of strongly coupled metal-metal oxide-graphene nanostructure with excellent electrocatalytic activity and durability. ACS Applied Materials & Interface, 2014, 6: 10258-10264.

    (25)Xunfu Zhou, Yingju Liu*, Xin Li, Qiongzhi Gao, Xiaotang Liu, Yueping Fang*. Topological morphology conversion towards SnO2/SiC hollow sphere nanochains with efficient photocatalytic hydrogen evolution. Chemical Communications, 2014, 50: 1070-1073.

    (26)Yingqiang Huang, Yingju Liu*, Zhuohong Yang, Jinliang Jia, Xin Li, Yan Luo, Yueping Fang. Synthesis of Yolk/shell Fe3O4-polydopamine-graphene-Pt nanocomposite with high electrocatalytic activity for fuel cells. Journal of Power Sources, 2014, 246: 868-875.

    (27)Yuan Lin, Yan WangZherong JiXueyi Le*. Isolation, Purification, and Identification of Coconut Protein through SDS-PAGE, HPLC, and MALDI-TOF/TOF-MS. Food Analytical Methods,doi.org/10.1007/s12161-020-01743-1

    (28)Chunlian Zhang, Daihong Cai, Shi  Chen, Wei Liu, Yahong Xiong, Xueyi Le*. Synthesis, DNA interaction and SODlike activities of copper(II) complexes: investigation of their DNAinteraction mechanism. Transition Metal Chemistry, 2019, 44:603613.

    (29)Yujia Liu, Danyang Ying, Luz Sanguansri, Yanxue Cai, Xueyi Le*. Adsorption of catechin onto cellulose and its mechanism study: Kinetic models, characterization and molecular simulation. Food Research International, 2018, 12, 225-232

    (30)Chunlian Zhang, Yaxian Liu, Xuemei Zhang, Shi Chen, Fang Shen, Yahong Xiong, Wei Liu,, Zongwan Mao, Xueyi Le*. Synthesis, characterization, DNA/HSA interactions and in vitro cytotoxic activities of two novel water-soluble copper(II) complexes with 1,3,5-triazine derivative ligand and amino acids. Materials Science & Engineering C, 2018, 91,414425

    (31)Yujia Liu, Yanxue Cai, Danyang Ying, Yinlian Fu, Yahong Xiong, Xueyi Le*. Ovalbumin as a carrier to significantly enhance the aqueous solubility and photostability of curcumin: Interaction and binding mechanism study. International Journal of Biological Macromolecules, 2018, 116, 893900

    (32)Yongyu Qi, Qian Gan , Yaxian Liu, Yahong Xiong, Zongwan Mao, Xueyi Le*. Two new Cu(II) dipeptide complexes based on 5-methyl-2-(2-pyridyl)benzimidazole as potential antimicrobial and anticancer drugs: special exploration of their possible anticancer mechanism. European Journal of Medicinal Chemistry, 2018, 154, 220-232

    (33)Yaxian Liu, Huiwen Mo, Zhenyu Lv, Fang Shen,Chunlian Zhang,Yongyu Qi, Zongwan Mao, Xueyi Le*. DNA binding, crystal structure, molecular docking studies and anticancer activity evaluation of a copper(II) complex. Transition Metal Chemistry, 2018, 43(3):259271

    (34)Chunlian Zhang, Xuemei Zhang, Wei Liu, Shi Chen*,Xueyi Le*. A copper(II) complex of 6(pyrazin2yl)1,3,5triazine2,4diamine and Lserinate: synthesis, crystal structure, DNAbinding and molecular docking studies. Transition Metal Chemistry, 2018, 43(3): 201209

    (35)Fang Shen,Yaxian Liu,Shumin Li,Chikun Jiang,Bingfeng Wang, Yahong Xiong*, Zongwan Mao, Xueyi Le*, Synthesis, crystal structures, molecular docking and in vitro cytotoxicity studies of two new copper(II) complexes: special emphasis on their binding to HSA, New Journal of Chemistry, 2017, 41, 12429-12441

    (36)Yujia Liu, Danyang Ying, Yanxue Cai, Xueyi Le*, Improved antioxidant activity and physicochemical properties of curcumin by adding ovalbumin and its structural characterization. Food Hydrocolloids, 2017,72, 304-311.

    (37)Fang Shen, Zhibin Ou, Yujia Liu , Wei Liu , Bingfeng Wang, Zongwan Mao, Xueyi Le*. Two Cu(II) complexes containing 2,4-diamino-6-(2-pyridyl)-1,3,5-triazine and amino acids: Synthesis, crystal structures, DNA/HSA binding, molecular docking, and in vitro cytotoxicity studies. Inorganica Chimica Acta. 2017, 465, 1-13.

    (38)Qian Gan, Yongyu Qi, Yahong Xiong, Yinlian Fu, Xueyi Le*. Two New Mononuclear Copper(II)-Dipeptide Complexes of 2-(2-Pyridyl)Benzoxazole: DNA Interaction, Antioxidation and in Vitro Cytotoxicity Studies. Journal of Fluorescence, 2017, 27: 701-714.

    (39)Qian Gan, Xiabing Fu,  Weijiang Chen,  Yahong Xiong,  Yinlian Fu,  Shi Chen,  Xueyi Le*. Synthesis, DNA/HSA Interaction Spectroscopic Studies and In Vitro Cytotoxicity of a New Mixed Ligand Cu(II) Complex. Journal of Fluorescence, 2016, 26: 905-918.

    (40)Yujia Liu, Yanxue Cai, Xueying Jiang, Jinping Wu, Xueyi Le*, Molecular interactions, characterization and antimicrobial activity of curcumin-chitosan blend films. Food Hydrocolloids, 2016, 52, 564-572.

    (41)Dandan Liu, Hua Su, Qian Cao, Xueyi Le* and Zongwan Mao*. Identifying the existence of highly-fluorescent carboxylic group-rich carbon nanodots during a one-pot synthesis of branched polyethyleniminepassivated amine group-rich carbon nanodots. RSC Adv., 2015, 5, 40588-40594.

    (42)Yujia Liu, Dandan Liu, Li Zhu, Qian Gan, Xueyi Le*,Temperature-dependent structure stability and in vitro release of chitosan-coated curcumin liposome. Food Research International, 2015, 74, 97-105.

    (43)Li Zhu, Zhi-Bin Ou, Jinliang Jia, Yunfei Hu, Xueyi Le*. A Novel Cu(II) Coordination PolymerContaining Single-stranded Helical Chains: Crystal Structure, Thermal Stability, and Fluorescent Property. Mol. Cryst. Liq. Cryst., , 2015, 606(1): 262271.

    (44)Xiabing Fu, Jiajia Zhang, Dandan Liu, Qian Gan, Hongwei Gao, Zongwan Mao, Xueyi Le*. Cu(II)dipeptide complexes of 2-(4-thiazolyl)benzimidazole: Synthesis, DNA oxidative damage,  antioxidant and in vitro antitumor activity. Journal of Inorganic Biochemistry, 2015, 143, 7787.

    (45)Xiabing Fu, Dandan Liu, Yuan Lin, Wei Hu, Zongwan Mao and Xueyi Le*. Water-soluble DNA minor groove binders as potential chemotherapeutic agents: synthesis, characterization, DNA binding and cleavage, antioxidation, cytotoxicity and HSA interactions. Dalton Trans., 2014, 43, 8721-8737.

    (46)Zhibin Ou, Jiamin Su, Xiabing Fu, Yanmei Lu, Xueyi Le*. Synthesis, Structure, and DNA Interaction of a New Ternary Copper(II) Complex With 2-(4-thiazolyl)benzimidazole and L-isoleucinate. Synthesis and Reactivity in Inorganic, Metal-Organic,and Nano-Metal Chemistry. 2014,44(7): 959-966.

    (47)Xiabing Fu, Zihua Lin, Haifeng Liu, Xueyi Le*. A new ternary copper(II) complex derived from 2-(20-pyridyl)benzimidazole and glycylglycine: Synthesis, characterization,DNA binding and cleavage, antioxidation and HSA interaction. Spectrochimica Acta Part A: Molecular and  Biomolecular Spectroscopy,2014,122: 22-33.

    (48)Xiabing Fu, Guitian Weng, Dandan Liu, Xueyi Le*, Synthesis, characterization, DNA binding and cleavage, HAS interaction and cytotoxicity of a new copper(II) complex derived from2-(2_- pyridyl)benzothiazole and glycylglycine. Journal of Photochemistry and Photobiology A: Chemistry, 2014,276: 83-95.

    (49)刘启雁, 蔡戴宏, 戚永育, 乐学义*. 司帕沙星及均三嗪衍生物铜(II)配合物与DNA作用及其抗肿瘤活性.化学学报,2020, 78, 263-270

    (50)Liu W , Zhou X , Xing D* . Rapid and reliable microRNA detection by stacking hybridization on electrochemiluminescent chip system[J]. Biosensors and Bioelectronics, 2014, 58:388-394.

    (51)Liu W , Zhu M , Liu H , et al. Invading stacking primer: A trigger for high-efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants[J]. Biosensors & Bioelectronics, 2016, 81:309-316.

    (52)Liu W , Yu H , Zhou X* , et al. In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay[J]. Analytical Chemistry, 2016, 88(17):8369-8374.

    (53)Liu H , Liu W , Yang X , et al. Paper-based bipolar electrode electrochemiluminescence switch for label-free and sensitive genetic detection of pathogenic bacteria[J]. Analytical Chemistry, 2016, 88(20).

    (54)Kang-Nan Wang, Xiang-Jun Peng, Yi Li, Hai-Tao Tang, Ying-Ming Pan*, Liang He*. Photostable fluorescent probes for 3D imaging and monitoring the metabolism of lipid droplets. Dyes and Pigments, 2020, accepted.

    (55)Wei-Wei Qin, Zheng-Yin Pan, Dai-Hong Cai, Yi Li and Liang He*. Cyclometalated iridium(III) complexes for mitochondria-targeted combined chemo-photodynamic therapy. Dalton Transactions, 2020, 49, 35623569.

    (56)Liang He*, Ming-Fang Zhang, Zheng-Yin Pan, Kang-Nan Wang, Zi-Jian Zhao, Yi Li and Zong-Wan Mao*. A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells. Chemical Communications, 2019, 55, 1047210475.

    (57)Liang He*, Zheng-Yin Pan, Wei-Wei Qin, Yi Li, Cai-Ping Tan* and Zong-Wan Mao*. Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(I) complex. Dalton Transactions, 2019, 48, 43984404.

    (58) Liang He, Jian-Jun Cao, Dong-Yang Zhang, Liang Hao, Ming-Fang, Zhang, Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*. Lipophilic phosphorescent iridium(III) complexes as one- and two-photon selective bioprobes for lipid droplets imaging in living cells. Sensors and actuators B-chemical, 2018, 262, 313325.

    (59)Liang He, Kang-Nan Wang, Yue Zheng, Jian-Jun Cao, Ming-Fang Zhang, Cai-Ping Tan, Liang-Nian Ji and Zong-Wan Mao*. Cyclometalated iridium(III) complexes induce mitochondria derived paraptotic cell death and inhibit tumor growth in vivo. Dalton Transactions, 2018, 47, 69426953.

    (60)Liang He, Cai-Ping Tan, Qian Cao and Zong-Wan Mao*. Application of Phosphorescent Cyclometalated Iridium(III) Complexes in Cancer Treatment. Progress in Chemistry, 2018, 30, 15481556.

    (61) Liang He, Yi Li, Cai-Ping Tan*, Rui-Rong Ye, Mu-He Chen, Jian-Jun Cao, Liang-Nian Ji and Zong-Wan Mao*. Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chemical Science, 2015, 6, 54095418.(Back Cover)

    (62)Liang He, Cai-Ping Tan*, Rui-Rong Ye, Yi-Zhi Zhao, Ya-Hong Liu, Qiang Zhao, Liang-Nian Ji and Zong-Wan Mao*. Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angewandte Chemie-International Edition, 2014, 53, 1213712141.

    (63) Liang He, Si-Yan Liao, Cai-Ping Tan*, Yi-Ying Lu, Cui-Xia Xu, Liang-Nian Ji and Zong-Wan Mao*. Cyclometalated iridium(III)–β-carboline complexes as potent autophagy-inducing agents. Chemical Communications, 2014, 50, 56115614.

    (64)Liang He, Si-Yan Liao, Cai-Ping Tan*, Rui-Rong Ye, Yu-Wen Xu, Meng Zhao, Liang-Nian Ji and Zong-Wan Mao*. Rutheniumarene–β-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chemistry-a european journal, 2013, 19, 1215212160.

    (65)Zhiru Wang, Weiwei Qin*, Jialang Zhuang, Minhao Wu, Qian Li, Chunhai Fan, Yuanqing Zhang *Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws. ACS Appl. Mater. Inter. 2019, 11, 12244-12252.

    (66) Weiwei Qin, Tianhuan Peng, Yanjing Gao, Fei Wang, Xiaocai Hu, Kun Wang, Jiye Shi, Di Li*,  Ren J., Fan C., Catalysis-Driven Self-Thermophoresis of Janus Plasmonic Nanomotors. Angew. Chem. Int. Ed. 2017, 56, 515-518.

    (67) Weiwei Qin, Guan Huang, Zuanguang Chen, Yuanqing Zhang*, Nanomaterials in Targeting Cancer Stem Cells for Cancer TherapyFront. Pharmacol., 2017, 8: 1-5.

    (68) Weiwei Qin, Lele Sun, Tianhuan Peng, Yan Xu, Yanjing Gao, Di Li, Recent progresses in molecule motors driven by enzymatic reactions. Chinese Journal of Analytical Chemistry, 2016, 44: 1133-1138.

    (69) Weiwei Qin, Shaopeng Wang, jiang Li, Tianhuan Peng, Yan Xu, Kun Wang, Jiye Shi, Chunhai Fan, Di Li*, Visualizing dopamine released from living cells using a nanoplasmonic probe. Nanoscale 2015, 7: 15070-15074.

    (70) Tianhuan Peng+, Weiwei Qin+, Kun Wang, Jiye Shi, Chunhai Fan, Di Li*, Nanoplasmonic Imaging of Latent Fingerprints with Explosive RDX Residues. Anal. Chem. 2015, 87:  9703-9407.

    (71)Shengbing Hu, Huimin Hu, Wenlong Li, Xiaxiao Hong, Daihong Cai, Jiawei Lin, Minghua Li and Yuechun Zhao*.Investigating the biodegradation of Sulfadiazine in Soil by Entero-bacter cloacae T2 immobilized on bagasse. RSC Advances, 2020, 10: 1142-1151.

    (72) Shengbing Hu, Huimin Hu, Wenlong Li, Yaoyi Ke, Minghua Li, Yuechun Zhao*. Enhanced sulfamethoxazole degradation in soil by immobilized sulfamethoxazole-degrading microbes on bagasse. RSC Advances, 2017,7: 55240-55248.

    (73) Di Cui, Peng Zhang, Yuhui Ma, Xiao He,Yuanyuan Li, Jing Zhang, Yuechun Zhao*, Zhiyong  Zhang*. Effect of Cerium Oxide Nanoparticles on Asparagus Lettuce Cultured in an Agar Medium.Environmental Science Nano, 2014, 1 (5): 459-465.

    (74)]Yanan Wei, Bingfeng Wang, Xinfang Cui, Yaseen Muhammad, Yanjuan Zhang, Zuqiang Huang, Xuesheng Li, Zhenxia Zhao, and Zhongxing Zhao.Highly Advanced Degradation of Thiamethoxam by synergistic chemisorption-catalysis strategy using MIL(Fe)/Fe-SPC composite with ultrasonic irradiation.2018,41:35260-35272.

    (75)Zijie Luo, Bin Liu, Kangning Zhu, Yingying Huang, Chengjun Pan*, Bingfeng Wang*, Lei Wang*. An environment-sensitive fluorescent probe for quantification of human serum albumin: Design, sensing mechanism, and its application in clinical diagnosis of hypoalbuminemia. Dyes and Pigments. 2018, 152:60-66.

    (76)Shi Chen#, Mohammed Esmail Abdalla Elzaki#, Chaohui Ding , Zheng-fang Li , Jie Wang , Ren-sen Zeng*, Yuan-Yuan Song*. Plant allelochemicals affect tolerance of polyphagous lepidopteran pest Helicoverpa armigera (Hübner) against insecticides, Pesticide Biochemistry and Physiology, 2019, 154:32-38

    (77)Zhongxiang Sun#, Cuicui Xu#, Shi Chen#, Qi Shi, Huanhuan Wang, Rumeng Wang,Yuanyuan Song*, and Rensen Zeng*. Exposure to Herbicides Prime P450-Mediated Detoxification of Helicoverpa armigera againstInsecticide and Fungal Toxin, Insects , 2019, 10(1):28

    (78)Chunlian Zhang, Xuemei Zhang,Wei Liu, Shi Chen*, Zong-Wan Mao, Xue-Yi Le*. Synthesis, crystal structures and DNA/human serum albumin binding of ternary Cu(II) complexes containing amino acids and 6-(pyrazin-2-yl)-1,3,5-triazine -2,4-diamino. Applied Organometallic Chemistry, 2018, 32(2)

    (79) Jiahong Lin, Qiujie Lai, Yingju Liu, Shi Chen*, Xueyi Le, Xiaohua Zhou. Laccase  methacrylyol functionalized magnetic particles: Highly immobilized, reusable, and efficacious for methyl red, International Journal of Biological Macromolecules, 2017, 102:144-152.

    (80) Jiahong Lin, Qilin Wen, Shi Chen*, Xueyi Le, Xiaohua Zhou, Limei Huang. Synthesis of amine-functionalized Fe3O4@C nanoparticles for laccase immobilization, International Journal of Biological Macromolecules, 2017, 96:377-383.

    (81) Jiahong Lin, Yingju Liu, Shi Chen*, Xueyi Le, Xiaohua Zhou, Zhiyong Zhao, Yiyi Ou, Jianhua Yang. Reversible immobilization of laccase onto metal-ion -chelatedmagnetic microspheres for bisphenol A removal, International Journal of Biological Macromolecules, 2016, 84:186-199.

    (82)Jiahong Lin, Ling Fan, Runli Miao, Xueyi Le, Shi Chen, Xiaohua Zhou. Enhancing catalytic performance of laccase via immobilization on chitosan/CeO2 microspheres. International Journal of Biological Macromolecules, 2015, 78:1-8.

    2、专利
          (1)
    乐学义,甘乾,一种苯并咪唑衍生物二肽铜配合物及其制备方法和应用,ZL 201510909362.7,授权日:2019.01.08

    (2) 乐学义,马玲龙,朱丽,熊亚红,陈实. 地奥司明-()配合物及其制备方法和应用,中国发明专利,申请号:201910589834.3,申请日:2019.10.25

      (3) 刘英菊,刘伟鹏,黄楚辉,黄银霞。 一种试剂变质自动检测方法及系统.发明专利,专利号:201710647153.9,申请日:2017.8.1.

    (4) 刘英菊 , 刘伟鹏 , 黄楚辉。一种软管防脱落连接装置.实用新型专利,专利号:201720754580.2,授权日:2017.12.1.

    (5) 刘英菊,林锐杰,黄浩量,黄伟豪,黄俊颖,林嘉栋。一种MoS2-CNT 多级纳米结构电解水制氢材料的制备方法.发明专利,专利号:ZL2016108859807,授权日:2018.9.25.

    (6) 刘英菊甘翠芬何祖宇魏婕敖日其冷。一种基于DNA 功能化纳米复合材料的电化学免疫传感器. 发明专利,专利号:ZL201610968342.1,授权日:2019.1.15.

    (7) 刘英菊,郑俭锋,高丹,孙子洪,何祖宇。一种环境激素检测装置及检测方法. 发明专利,专利号:ZL201510466528.2,授权日:2017.8.11.

    (8) 刘英菊甘翠芬,常惟丹,蔡悦,刘伟鹏。一种纳米生物双重模拟酶传感器的制备及其应用. 发明专利,专利号:201810711500.4,申请日:2018.7.3.

     (9) 刘英菊,刘莹,魏婕,申浩然,陈华明。一种基于酶诱导生物刻蚀双模分离式免疫传感器及其制备方法,发明专利,专利号:201910183819.9,申请日:2019. 03.12

    (10) 刘英菊,梁弘志,敖日其冷,谢玄,张悦。一种比率型广谱性光电免疫传感器的制备方法,发明专利,专利号:201910184008.0,申请日:2019. 03.12

    (11) 赵月春,莫测辉。一种修复DDT污染土壤的方法,发明专利,专利号:ZL200710032998.8,授权日:2011.3.23

    (12)赵月春,马伟娟。一种菌酶联合修复土壤DDT污染的方法,发明专利,专利号:ZL 201110022829.8,授权日:2012.8.22

    五、学生培养情况
     (1)
    2014年以来,培养学术型硕士生近20人,大部分获得校级优秀硕士学位论文及校级优秀研究生。
     (2)
    研究生:留学基金委资助出国攻读博士学位:林谋宏、黄浩量;国家奖学金:林谋宏、黄浩量、臧帅、甘翠芬、魏婕、何祖宇、敖日其冷、蔡跃;广东省优秀硕士论文:林谋宏;广东省优秀研究生:敖日其冷

    (3) 本科生:2011.5,广东省大学生挑战杯一等奖;2013.5,广东省大学生挑战杯一等奖;2012.3,华南地区“白云杯”材料创新大赛三等奖;2012.5,广东省生化技能大赛三等奖;2013.8,广东省化学实验技能大赛三等奖;2015.5,广东省大学生挑战杯特等奖;2015.11,全国大学生挑战杯三等奖;2017.6,广东省大学生挑战杯一等奖;2017.11,全国大学生挑战杯三等奖;2018.12,广东省高校化学化工实验安全知识竞赛特等奖、一等奖等。


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