一、个人基本资料

姓名：刘伟鹏

性别：男

出生年月：1987.9

籍贯：黑龙江

职位：硕士生导师

二、联系方式

邮箱：weipeng_liu@scau.edu.cn

通讯地址：广州市天河区华南农业大学材料与能源学院应用化学系

邮编：510642

三、个人简介

2016年7月，进入华南农业大学材料与能源学院应用化学系从事教学和科研工作，副教授，硕士生导师，化工与制药副系主任。研究方向核酸、纳米材料增敏技术构建；异质界面层核酸分子动力学研究；便携式生物传感器开发。现主持国家自然科学基金2项、广东省自然科学基金2项、广州市科学计划2项。已在Advanced Functional Materials, Small, Analytical Chemistry, Biosensors & Bioelectronics等生物传感和纳米材料领域的国际期刊发表研究论文30余篇。

四、教育背景（依次介绍博士、硕士、本科）

(1) 2006-2010年，山东大学，生命科学学院，获理学学士学位；

(2) 2010-2016年，华南师范大学，生物光子学研究院，获理学博士学位。

五、工作经历（主要工作简历+主要学术兼职）

(1) 2016年至2019年，华南农业大学材料与能源学院，首聘副教授；

(2) 2020年至今，华南农业大学材料与能源学院，副教授。

六、科研方向

(1) 生物传感器制备

(2) 分子诊断

七、科研项目

1. 国家自然科学基金委员会，面上项目，32470085，基于单粒子微反应室的DNA绝对定量技术探究及其在农业病害检测中的应用，2025-01至2028-12,50万元，在研，主持

2.国家自然科学基金委员会，面上项目，32170100，基因靶向识别的可编程逻辑门构建及其在马铃薯晚疫病检测中的应用，2022-01至2025-12,58万元，在研，主持

3. 广东省自然科学基金，面上项目，2023A1515012871，面向农业病害即时诊断的DNA水凝胶自供能传感器构建，2023-01至2025-12，10万元，在研，主持

4. 广州市科学技术局，基础与应用基础研究专题（优秀博士“续航”项目），2024A04J5241，马铃薯晚疫病数字化单分子检测体系构建，2024-01至2025-12，10万元，在研，主持

5. 广州市科学技术局，基础研究计划，202102020511，基因靶向识别的分子逻辑门构建及其在晚疫病检测中的应用，2021-04至2023-03，5万，结题，主持

6. 国家自然科学基金委员会，青年项目，21705051，基于基因靶向切割的核酸扩增技术构建及其在马铃薯晚疫病检测中的应用，2018-01至2020-12，25万元，结题，主持

7. 广东省自然科学基金管理委员会，面上项目，2017A030313077，纳米粒子介导的CRISPR/Cas9系统胞内缓释释放，2017-05至2020-05，10万元，结题，主持

八、科研论著

1. Hongzhi Liang, Shizhang Chen, Aori Qileng, Haoran Shen, Weipeng Liu*, Zhenlin Xu, Shengsen Zhang, Yingju Liu*.. Enhanced photothermal activity of nanoconjugated system via covalent organic frameworks as the springboard. Small, 2024, 20: 2304720. (IF: 15.513; 一区)

2. Haoran Shen, Guosheng Cui, Hongzhi Liang, Hui Yang, Mengting Chen, Zhen-Lin Xu, Weipeng Liu,* Yingju Liu*. DNA nanomachine-driven heterogeneous quadratic amplification for sensitive and programmable miRNA profiling. Analytical Chemistry, 2023, 95: 15765-15777. （封面论文）

3. Hui Yang, Haoran Shen, Aori Qileng, Guosheng Cui, Ziqing Liang, Yingju Liu*, Weipeng Liu*. Well-aligned track-accelerated tripedal DNA walker for photoelectrochemical recognition of dual-miRNAs nased on molecular logic gates. Analytical Chemistry, 2023, 95: 5764−5772. (IF: 8.008; 一区)

4. Guosheng Cui, Min Li, Aori Qileng, Hui Yang, Mengting Chen, Weipeng Liu*, Yingju Liu*. Cesium-lead-halide perovskite triggered visual platform: disposable paper-based nano-temperature sensor for cold chain transport. Journal of Material Chemistry C, 2023, 11: 10843-10851.

5. Aori Qileng^#, Weipeng Liu^#, Hongzhi Liang, Mengting Chen, Haoran Shen, Shizhang Chen,* and Yingju Liu*. Tuning the Electronic Configuration of Oxygen Atom in Engineering Non-Self-Limited Nanozyme for Portable Immunosensor. Advanced Functional Materials, 2024, 34: 2311783.

6. Hui Yang, Liying Ge, Ziqing Liang, Haoran Shen, Yingju Liu,*, Kaiyu He,*, Weipeng Liu*.A Distance-Adjustable 3D DNA Scaffold Accelerated Quadruped DNA Walker for the Photoelectrochemical Biosensing of RNA in Phytophthora infestans. Journal of Analysis and Testing, 2024, in press.

7. Mengting Chen, Aori Qileng, Hongzhi Liang, Hongtao Lei, Weipeng Liu*, Yingju Liu*. Advances in immunoassay-based strategies for mycotoxin detection in food: from single-mode immunosensors to dual-mode immunosensors. Comprehensive Reviews in Food Science and Food Safety, 2023, 22: 1285-1311

8. Mengting Chen, Xiaomeng Huang, Yuxuan Chen, Yiran Cao, Shengsen Zhang, Hongtao Lei, Weipeng Liu*, Yingju Liu*. Shape-specific MOF-derived Cu@Fe-NC with morphology-driven catalytic activity: Mimicking peroxidase for the fluorescent- colorimetric immunosignage of ochratoxin. Journal of Hazardous Materials, 2023, 443: 130233.

9. Shen Haoran, Qileng Aori, Yang Hui, Liang Hongzhi, Zhu Hongshuai, Liu Yingju*, Lei Hongtao*, Liu Weipeng*. “Dual-Signal-On” Integrated-Type Biosensor for Portable Detection of miRNA: Cas12a-Induced Photoelectrochemistry and Fluorescence Strategy. Analytical Chemistry, 2021. doi: 10.1021/acs.analchem.1c02395

10. Xinyue Zha, Weiwei Qin, Jiadi Chen, Mengting Chen, Qiyue Zhang, Kaiyu He, Yingju Liu*, Weipeng Liu*. Anchoring red blood cell with tetrahedral DNA nanostructure: electrochemical biosensor for the sensitive signage of circulating tumor DNA. Talanta, 2023, 251: 123793. (IF: 6.556; 一区)

11. Haoran Shen, Hui Yang, Aori Qileng, Yidan Ma, Hongzhi Liang, Jingnan Meng, Hongtao Lei, Yingju Liu*, Weipeng Liu*. Programmable readout sensor for microRNA: CRISPR/Cas12a-assisted multi-amplification strategy activated photoelectrochemistry- colorimetry detection. Sensors and Actuators B-Chemical, 2022, 371: 132585. (IF: 9.221; 一区)

12. Zexuan Liu, Mengting Chen, Wenwen Feng, Yiqiao Lin, Weipeng Liu*, Yingju Liu*. CoS2/N-doped carbon nanotubes hollow polyhedron derived from core-shell ZIF-8@ZIF-67 for efficient hydrogen evolution reaction. International Journal of Hydrogen Energy, 2023, 48: 9362-9370.

13. Aori Qileng, Weipeng Liu, Ziqi Sun, Weichi Zhou, Yueping Fang, Hongtao Lei, Yingju Liu*, Shengsen Zhang*. Portable dual-modular immunosensor constructed from bimetallic metal-organic-framework heterostructure grafted with enzyme-mimicking label for rosiglitazone detection. Advanced Functional Materials, 2022, 32: 2203244.

14. Zhu, Hongshuai; Liu, Chuanhe; Liu, Xinxin; Quan, Zhu; Liu, Weipeng*; Liu, Yingju*; A multi-colorimetric immunosensor for visual detection of ochratoxin A by mimetic enzyme etching of gold nanobipyramids, Microchimica Acta, 2021, 188(3): 62.

15. Chang, Weidan#; Liu, Weipeng*#; Shen, Haoran; Chen, Sisi; Liao, Peizhen; Liu, Yingju*; Molecular AND logic gate for multiple single-nucleotide mutations detection based on CRISPR/Cas9n system-trigged signal amplification, Analytica Chimica Acta, 2020, 1112: 46-53.  

16. Cai, Yue; Fang, Jingkun; Zhu, Hongshuai; Qin, Weiwei; Cao, Yiran; Yu, Huijuan; Shao, Guang*; Liu, Yingju*; Liu, Weipeng*; A Rapid off-on copper-induced AIE active sensor for fluorimetric detection of cysteine, Sensors and Actuators B: Chemical, 2020, 303: 127214.

17. Liu, Weipeng; Gan, Cuifen; Chang, Weidan; Qileng, Aori; Lei, Hongtao; Liu, Yingju*; Double-integrated mimic enzymes for the visual screening of Microcystin-LR: Copper hydroxide nanozyme and G-quadruplex/hemin DNAzyme, Analytica Chimica Acta, 2019, 1054: 128-136.

18. Chang, Weidan#; Liu, Weipeng#; Liu, Ying; Zhan, Fangfang; Chen, Huifang; Lei, Hongtao; Liu, Yingju*; Colorimetric detection of nucleic acid sequences in plant pathogens based on CRISPR/Cas9 triggered signal amplification, Microchimica Acta, 2019, 186(04): 243-250.

19. Qileng, Aori; Yang, Siyuan; Wei, Jie; Lu, Ning; Lei, Hongtao; Liu, Yingju*; Liu, Weipeng*; Construction of CdS/Ag2S-based broad-spectrum photoelectrochemical immunosensor for simultaneous assessment of ochratoxins by multivariable linear regression, Sensors and Actuators B: Chemical, 2018, 267: 216-223.

20. Gan, Cuifen; Wang, Bingfeng; Huang, Junying; Qileng, Aori; He, Zuyu; Lei, Hongtao; Liu, Weipeng*; Liu, Yingju*; Multiple amplified enzyme-free electrochemical immunosensor based on G-quadruplex/hemin functionalized mesoporous silica with redox-active intercalators for microcystin-LR detection, Biosensors and Bioelectronics, 2017, 98: 126-133.

21. He, Zuyu; Cai, Yue; Yang, Ziming; Li, Puwang; Lei, Hongtao; Liu, Weipeng*; Liu, Yingju*;  A dual-signal readout enzyme-free immunosensor based on hybridization chain reaction-assisted formation of copper nanoparticles for the detection of microcystin-LR, Biosensors and Bioelectronics, 2019, 126: 151-159.

22. Huang, Haoliang; Huang, Weihao; Yang, Zhuohong; Huang, Junying; Lin, Jiadong; Liu, Weipeng*; Liu, Yingju*; Strongly coupled MoS2 nanoflake-carbon nanotube nanocomposite as an excellent electrocatalyst for hydrogen evolution reaction, Journal of Materials Chemistry A, 2017, 5(4): 1558-1566.

23. He, Zuyu; Wei, Jie; Gan, Cuifen; Liu, Weipeng*; Liu, Yingju*; A rolling circle amplification signal-enhanced immunosensor for ultrasensitive microcystin-LR detection based on a magnetic graphene-functionalized electrode, RSC Advances, 2017, 7(63): 39906-39913.

24. Liu, Weipeng; Yu, Huiheng; Zhou, Xiaoming*; Xing, Da*; In Vitro Evaluation of CRISPR/Cas9 Function by an Electrochemiluminescent Assay. Analytical Chemistry, 2016, 88(17): 8369-8374.  

25. Liu Weipeng; Zhu Minjun; Liu Hongxing; Wei Jitao; Zhou Xiaoming*; Xing Da*; Invading stacking primer: A trigger for high efficiency isothermal amplification reaction with superior selectivity for detecting microRNA variants, Biosensors and Bioelectronics, 2016, 81(81): 309-316.  

九、写给学生的话

   良好的心态是生活、工作、科研的最佳催化剂！