邀请学术报告
我们有幸邀请到香港浸会大学化学系黄嘉良博士和中国科学院城市环境研究所张洪武研究员来我院做学术报告。报告内容有关于发光材料在医学成像中的最新应用进展。欢迎各位老师和同学们积极参加。
报告时间：2017年5月22日 星期一 上午 9点30分
会议地点：材料与能源学院北楼231（教工之家）
主持人：雷炳富 教授
以下是详细内容介绍。
学术报告(一)
Biocompatible lanthanide materials for tumors targeting, imaging and inhibition
报告人：黃嘉良 博士
报告摘要：
One of the major limitations of the existing anticancer agents is their differentiation of cancer cells and normal cells. Recently, some studies in the literature have suggested that some overexpressed cancer cell cycle regulating proteins (e.g. Cyclin(s), Plk1 and EBNA1) can be the particular cancer targets. Several small molecules as their inhibitors have been reported; however, those reported inhibitors are not emissive and cannot directly evaluate their effectiveness, such as real time imaging, biodistribution and pharmacokinetic studies. Over the recent two decades, luminescent lanthanide materials have shown extensive applications in the detection of various bioactive molecules and for in vitro/in vivo imaging, addressing the problem of autofluorescence. For this reason, one of our driving forces for synthesizing new lanthanide materials for imaging these cell cycle regulated protein relates to their unique photophysical properties, such as long emission lifetimes (effective elimination of biological auto-fluorescence in time-resolved spectroscopy) and characteristic hypersensitive emissions, (providing real-time information about the effect on coordination environment by surrounding entities, especially with europium) which are attractive substitutes to the more commonly used organic fluorophores.
In this seminar, I would like to share our development recently on emissive lanthanide materials as dual bioprobes for in vitro/in vivo imaging and inhibition of overexpressed tumor regulator proteins, such as Cyclin(s), Plk1 and EBNA1. It is hoped that the success in research could also lead to the success in practice, thereby providing more powerful tools to get more complete pictures of the roles of Cyclin(s)/Plk1/EBNA1.
学术报告(二)
长余辉纳米发光探针研发及其在活体成像中的应用
报告人：张洪武 研究员
报告摘要：
发光成像由于其具有原位实时以及高灵敏度的优势在生物成像中得到广泛应用，但生物体自发光现象噪声成像信噪比低，限制发光成像在生物体疾病检测中的进一步应用。长余辉发光成像由于是利用长余辉纳米发光颗粒在体外蓄光，注射体内缓慢释放发光成像的方法，这就可以避免了由于外界光源照射所产生的生物体自发光的影响，因而增强了成像的信噪比。
在我们的研究工作中，我们采用多种方法合成长余辉纳米颗粒，并通过对颗粒表面进行靶向修饰，形成对生物体病灶的靶向定位，并利用近红外光原位激发的方法实现了对病灶超长时间成像检测，这有利于对疾病成因、发展过程以及转移途径进行深入探究，从而形成有效治疗。同时，我们的研究也关注于细颗粒物进入生物体后对生物体所产生的影响，结合光学成像与代谢组学研究细颗粒物在体内迁移过程以及所产生的危害。
黃嘉良博士个人简历
Dr. Ka-Leung Wong, Associate Professor, Department of Chemistry, Hong Kong Baptist University. In 2006, he received his doctoral degree in Chemistry at the University of Hong Kong. He was awarded by the European Rare Earth and Actinide Society in 2015 the ERES Junior award. In this year he was also awarded the President’s Award for Outstanding Young Researcher (Hong Kong Baptist University). He is the International Advisory Board Member - ChemPlusChem, Wiley(2016-2019). His current research interests includes 1) Bioinorganic Chemistry, 2) luminescent materials, 3) sol-gel Chemistry and 4) lanthanide spectroscopy. He has published more than 100 publications (http://chem.hkbu.edu.hk/gary, h-index = 33, citations > 2600.
张洪武研究员个人简历
张洪武，中国科学院城市环境研究所研究员，研究方向：光学成像传感以及纳米生物效应方面的研究。2005年于中国科学院大连化学物理研究所获得博士学位，先后在日本产业综合研究所原位诊断实验室以及生产计测中心从事研究工作，于2010年获得中国科学院百人计划的资助，进入中国科学院城市环境研究所进行研究工作，2013年获得福建省百人计划的资助。目前研究组主要集中于长余辉纳米探针成像诊断以及疾病靶向治疗方面的研究，到目前为止已发表学术论文90余篇，其中第一及通讯作者SCI论文73篇。
