一、个人基本资料
姓名：何良
性别：男
出生年月：1987.7
籍贯：广东阳春
职位：副教授，硕士生导师
二、联系方式
邮箱：heliang@scau.edu.cn
通讯地址：广州市天河区华南农业大学材料与能源学院应用化学系
邮编：510642
个人科研主页：https://orcid.org/0000-0002-9090-3806
三、个人简介
中共党员，理学博士，副教授，硕士生导师。2016年毕业于中山大学，获博士学位，师从毛宗万教授。迄今为止，在Angew. Chem. Int. Ed.、Chem. Sci.、Eur. J. Med. Chem.等杂志上发表SCI论文30余篇。作为负责人主持国家自然科学基金、广东省自然科学基金等多项科研项目。主要承担《无机化学》、《配位化学》、《无机及分析化学实验》等课程的教学工作。
四、教育背景
1. 2011.09-2016.06，中山大学，化学学院，化学生物学，博士（硕博连读，导师：毛宗万教授）
2. 2007.09-2011.06，中山大学，化学学院，高分子材料与工程，学士
五、工作经历
1. 2018.09至今，华南农业大学，材料与能源学院，副教授/硕士生导师
2. 2016.09-2018.08，中山大学，化学学院，特聘副研究员
六、科研方向
课题组主要围绕新型抗肿瘤抗菌药物的开发、多功能生物材料的应用、分析检测新方法等开展工作。
七、科研论著
1. Dai-Hong Cai, Bin-Fa Liang, Bai-Hua Chen Qi-Yan Liu, Zheng-Yin Pan*, Xue-Yi Le*, Liang He*. A novel water-soluble Cu(II) gluconate complex inhibits cancer cell growth by triggering apoptosis and ferroptosis related mechanisms. J. Inorg. Biochem., 2023, 246: 112299.
2. Bai-Hua Chen, Zheng-Yin Pan, Wen-Wen Feng, Qi-Yan Liu, Yingju Liu*, Liang He*. Synthesis, characterization and biological activity of novel copper complexes containing a β-carboline derivative and amino acids. Dalton Trans., 2023, 52: 8040-8050.
3. Wen-Wen Feng, Bing-Fa Liang, Bai-Hua Chen, Qi-Yan Liu, Zheng-Yin Pan*, Ying-Ju Liu, Liang He*. A tricarbonyl rhenium(I) complex decorated with boron dipyrromethene for endoplasmic reticulum-targeted photodynamic therapy. Dyes and Pigments, 2023, 211: 111077.
4. Zheng-Yin Pan, Bing-Fa Liang, Yun-Shi Zhi, Da-Hong Yao*, Chen-Yang Li*, Hai-Qiang Wu*, Liang He*. Near-infrared AIE-active phosphorescent iridium(III) complex for mitochondria-targeted photodynamic therapy. Dalton Trans., 2023, 52: 1291-1300.
5. Zheng-Yin Pan, Wen-Wen Feng, Qi-Yan Liu, Liang He*, Da-Hong Yao*, Zhen-Dan He*. Lipophilic neutral iridium(III) complexes for phosphorescence imaging of lipid droplets and potential photodynamic therapy. Dyes and Pigments, 2022, 203: 110387.
6. Dai-Hong Cai, Bai-Hua Chen, Qi-Yan Liu, Xue-Yi Le*, Liang He*. Synthesis, structural studies, interaction with DNA/HSA and antitumor evaluation of new Cu(II) complexes containing 2-(1H-imidazol-2-yl)pyridine and amino acids. Dalton Trans., 2022, 51: 16574-16586.
7. Qi-Yan Liu, Yong-Yu Qi, Dai-Hong Cai, Yun-Jun Liu*, Liang He*, Xue-Yi Le*. Sparfloxacin-Cu(II)-aromatic heterocyclic complexes: synthesis, characterization and in vitro anticancer evaluation. Dalton Trans., 2022, 51: 9878-9887.
8. Xuling Xue, Ying Fu, Liang He (Co-first author), Luca Salassa, Ling-Feng He, Yuan-Yuan Hao, Madeleine J. Koh, Clément Soulie, Russell J. Needham, Abraha Habtemariam, Claudio Garino, Kirill A. Lomachenko, Zhi Su*, Yong Qian, Martin J. Paterson*, Zong-Wan Mao*, Hong-Ke Liu*, Peter J. Sadler*. Photoactivated Osmium Arene Anticancer Complexes. Inorg. Chem., 2021, 60: 17450–17461.
9. Dai-Hong Cai, Chun-Lian Zhang, Qi-Yan Liu, Liang He*, Yun-Jun Liu*, Ya-Hong Xiong, Xue-Yi Le*. Synthesis, DNA binding, antibacterial and anticancer properties of two novel water-soluble copper(II) complexes containing gluconate. Eur. J. Med. Chem., 2021, 213, 113182.
10. Dai-Hong Cai, Hui⁃Wen Mo, Liang He*, Xue-Yi Le*. Crystal Structure, DNA Binding Properties and Biological Activities of a Ternary Mixed-Ligand Copper(II) Complex. Chin. J. Inorg. Chem., 2021, 37(1):74-84.
11. Kang-Nan Wang, Xiang-Jun Peng, Yi Li, Hai-Tao Tang, Ying-Ming Pan*, Liang He*. Photostable fluorescent probes for 3D imaging and monitoring the metabolism of lipid droplets. Dyes and Pigments, 2020, 180, 108502.
12. Zheng-Yin Pan, Dai-Hong Cai, Liang He*. Dinuclear phosphorescent rhenium(I) complexes as potential anticancer and photodynamic therapy agents. Dalton Trans., 2020, 49, 11583–11590.
13. Wei-Wei Qin, Zheng-Yin Pan, Dai-Hong Cai, Yi Li, Liang He*. Cyclometalated iridium(III) complexes for mitochondria-targeted combined chemo-photodynamic therapy. Dalton Trans., 2020, 49, 3562–3569.
14. Liang He*, Ming-Fang Zhang, Zheng-Yin Pan, Kang-Nan Wang, Zi-Jian Zhao, Yi Li, Zong-Wan Mao*. A mitochondria-targeted iridium(III)-based photoacid generator induces dual-mode photodynamic damage within cancer cells. Chem. Commun., 2019, 55, 10472–10475.
15. Liang He*, Zheng-Yin Pan, Wei-Wei Qin, Yi Li,Cai-Ping Tan*, Zong-Wan Mao*. Impairment of the autophagy-related lysosomal degradation pathway by an anticancer rhenium(I) complex. Dalton Trans., 2019, 48, 4398–4404.
16. Liang He, Jian-Jun Cao, Dong-Yang Zhang, Liang Hao, Ming-Fang, Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao*. Lipophilic phosphorescent iridium(III) complexes as one- and two-photon selective bioprobes for lipid droplets imaging in living cells. Sensor. Actuat. B-Chem., 2018, 262, 313–325.
17. Liang He, Kang-Nan Wang, Yue Zheng, Jian-Jun Cao, Ming-Fang Zhang, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated iridium(III) complexes induce mitochondria derived paraptotic cell death and inhibit tumor growth in vivo. Dalton Trans., 2018, 47, 6942–6953.
18. Liang He, Cai-Ping Tan, Qian Cao, Zong-Wan Mao*. Application of Phosphorescent Cyclometalated Iridium (Ⅲ) Complexes in Cancer Treatment. Progress in Chemistry, 2018, 30, 1548–1556.
19. Liang He, Yi Li, Cai-Ping Tan*, Rui-Rong Ye, Mu-He Chen, Jian-Jun Cao, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated iridium(III) complexes as lysosome-targeted photodynamic anticancer and real-time tracking agents. Chem. Sci., 2015, 6, 5409–5418.(Back Cover)
20. Liang He, Cai-Ping Tan*, Rui-Rong Ye, Yi-Zhi Zhao, Ya-Hong Liu, Qiang Zhao, Liang-Nian Ji, Zong-Wan Mao*. Theranostic iridium(III) complexes as one- and two-photon phosphorescent trackers to monitor autophagic lysosomes. Angew. Chem. Int. Ed., 2014, 53, 12137–12141.
21. Liang He, Si-Yan Liao, Cai-Ping Tan*, Yi-Ying Lu, Cui-Xia Xu, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated iridium(III)–β-carboline complexes as potent autophagy-inducing agents. Chem. Commun., 2014, 50, 5611–5614.
22. Liang He, Si-Yan Liao, Cai-Ping Tan*, Rui-Rong Ye, Yu-Wen Xu, Meng Zhao, Liang-Nian Ji, Zong-Wan Mao*. Ruthenium–arene–β-carboline complexes as potent inhibitors of cyclin-dependent kinase 1: synthesis, characterization and anticancer mechanism studies. Chem. Eur. J., 2013, 19, 12152–12160.
23. Yue Zheng, Liang He, Dong-Yang Zhang, Cai-Ping Tan*, Liang-Nian Ji, Zong-Wan Mao*. Mixed-ligand iridium(III) complexes as photodynamic anticancer agents. Dalton Trans., 2017, 46, 11395–11407.
24. Rui-Rong Ye, Cai-Ping Tan*, Liang He, Mu-He Chen, Liang-Nian Ji, Zong-Wan Mao*. Cyclometalated Ir(III) complexes as targeted theranostic anticancer therapeutics: combining HDAC inhibition with photodynamic therapy. Chem. Commun., 2014, 50, 10945–10948.
25. Dong-Yang Zhang, Yue Zheng, Hang Zhang, Liang He, Cai-Ping Tan*, Jing-Hua Sun, Wei Zhang, Xingyun Peng, Qiuqiang Zhan, Liang-Nian Ji, Zong-Wan Mao*. Ruthenium complex-modified carbon nanodots for lysosome-targeted one- and two-photon imaging and photodynamic therapy. Nanoscale, 2017, 9, 18966–18976.
26. Yi Li, Cai-Ping Tan, Wei Zhang, Liang He, Liang-Nian Ji, Zong-Wan Mao*. Phosphorescent iridium(III)-bis-N-heterocyclic carbene complexes as mitochondria-targeted theranostic and photodynamic anticancer agent. Biomaterials, 2015, 39, 95–104.
八、科研项目
1. 广东省自然科学基金青年提升项目，基于无金属催化生物正交活化配合物策略的声动力免疫治疗研究，2024.01-2026.12，30万元，主持
2. 广东省自然科学基金面上项目，基于生物正交反应和代谢标记构建靶向激活的新型光敏剂用于肿瘤和细菌的精准治疗（2022A1515011356），2022.01-2024.12，10万元，主持
3. 广东省自然科学基金面上项目，基于磷光金属配合物的光致产酸剂用于乏氧肿瘤的双光子光动力治疗（2019A1515011280），2019.09-2022.09，10万元，主持
4. 广州市科技计划项目，肿瘤微环境靶向激活的磷光金属配合物的设计、合成及抗癌活性研究（202102021223），2021.04-2023.03，5万元，主持
5. 国家自然科学基金青年基金项目，靶向型磷光金属配合物诱导癌细胞免疫原性死亡的研究（21701195），2018.01-2020.12，25万元，主持
6. 广东省自然科学基金博士科研启动项目，靶向型的磷光金属配合物作为抗癌诊疗药物的研究（2017A030310278），2017.05-2020.04，10万元，主持
7. 高校基本科研业务费-中山大学青年教师培育项目，肿瘤微环境刺激响应的磷光金属配合物作为抗癌药物的研究，2017.01-2019.12，15万，主持
九、写给学生的话
越努力越幸运！
